Thermo Fisher Scientific IL21 Polyclonal Antibody, MaxPab
IL21에 특이적인 폴리클로날 항체로 인간 시료에 반응하며 Western blot에 적합합니다. PBS 기반 액상 형태로 제공되며, 보존제가 포함되지 않습니다. 친화 크로마토그래피로 정제되어 고순도 확보. 연구용으로만 사용 가능.
- 카탈로그번호
- H00059067-B01P
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | IL21 (NP_068575, 1–162 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MRSSPGNMER IVICLMVIFL GTLVHKSSSQ GQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
Target Information
IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17, and T follicular helper (TFH) cells.
In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which activates transcription by Bcl6.
IL-21 is critical for TFH cell development and effector function and plays a key role in T cell-dependent B cell differentiation into plasma and memory cells, IgG production, and apoptotic signaling in naive B cells.
In Th17 cells, IL-21 upregulates IL-23R through STAT3, IRF4, and RORγt, supporting maturation and maintenance by IL-23.
IL-21 also mediates downregulation of Foxp3. IL-21 deficient mice show resistance to chemically induced colitis due to impaired Th17-associated molecule expression, whereas elevated IL-21 levels are observed in colitis models.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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