Thermo Fisher Scientific IL21 Polyclonal Antibody, MaxPab

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MRSSPGNMER IVICLMVIFL GTLVHKSSSQ GQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS

Target Information

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer (NKT), T helper (Th) 17, and T follicular helper (TFH) cells.
In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, resulting in transcriptional activation by Bcl6.
Similar to IFN-γ for Th1 and IL-4 for Th2 cells, IL-21 is crucial for TFH cell development and effector function.
IL-21 plays a role in T cell-dependent B cell differentiation into plasma and memory cells, stimulates IgG production, and induces apoptotic signaling in naive B cells.
In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4, and RORγt upregulate IL-23R, preparing Th17 cells for maturation and maintenance by IL-23.
IL-21 also mediates the downregulation of Foxp3.
IL-21 deficient mice are protected from developing colitis due to failure to upregulate Th17-associated molecules, whereas elevated IL-21 levels are found in colitis models.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.