Thermo Fisher Scientific S100B (Astrocyte and Melanoma Marker) Monoclonal Antibody (S100B/4149)

Thermo Fisher Scientific S100B (Astrocyte and Melanoma Marker) Monoclonal Antibody (S100B/4149)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Stability: 24 months
• Positive Control: Human brain or melanoma tissue
• Cellular Localization: Cytoplasm, Nucleus

Specificity Comments:
S100 belongs to the family of calcium-binding proteins. S100A and S100B are two members of the S100 family.
S100A is composed of an alpha and a beta chain, whereas S100B consists of two beta chains.
This antibody recognizes an epitope on the beta-chain (present in S100A and S100B) but not on the alpha-chain (present in S100A and S100A0).
It can be used to localize S100A and S100B in various tissue sections.

S100 protein is found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, and glial cells.
Neoplasms derived from these cells also express S100 protein, though non-uniformly.
Many well-differentiated tumors of salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S100 protein.
Almost all malignant melanomas and cases of histiocytosis X are positive for S100 protein.

Target Information

S100B is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs.
S100 proteins are localized in the cytoplasm and/or nucleus of many cell types and regulate processes such as cell cycle progression and differentiation.
S100B may function in neurite extension, melanoma cell proliferation, Ca²⁺ flux stimulation, inhibition of PKC-mediated phosphorylation, astrocytosis, axonal proliferation, and inhibition of microtubule assembly.
Chromosomal rearrangements and altered expression of S100B have been linked to diseases including Alzheimer’s disease, Down’s syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.