Thermo Fisher Scientific Androgen Receptor Monoclonal Antibody (AR 441)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:200

View 33 publications 33 publications

Immunohistochemistry (IHC)

-

View 32 publications 32 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:25

-

Immunocytochemistry (ICC/IF)

1:25-1:50

View 4 publications 4 publications

Immunoprecipitation (IP)

1:25-1:50

View 3 publications 3 publications

ChIP assay (ChIP)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Yeast

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

AR 441

Immunogen

Synthetic peptide corresponding to Human Androgen Receptor aa 299-315 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Androgen Receptor,uniProtId:P10275-1,ncbiNodeId:9606,antigenRange:299-315,antigenLength:920,antigenImageFileName:MA5-13426_Androgen_Receptor_P10275-1_House_mouse.svg,antigenImageFileNamePDP:MA5-13426_Androgen_Receptor_P10275-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_11000751

Product Specific Information

MA5-13426 targets Androgen Receptor in ICC/IF, IHC (P), IP, and WB applications and shows reactivity with human samples.

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy`s disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.