Thermo Fisher Scientific TWEAK Polyclonal Antibody
인간 TWEAK 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 액상 형태로 제공됩니다. -20°C에서 보관하며, 세포 성장 및 염증 반응 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human TNFSF12 (aa 35–84) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2610268 |
Product Specific Information
- Peptide sequence: LGLLLAVVSL GSRASLSAQE PAQEELVAEE DQDPSELNPQ TEESQDPAPF
- Sequence homology:
- Dog: 79%
- Horse: 93%
- Human: 100%
- Mouse: 83%
- Rabbit: 83%
- Rat: 86%
- Zebrafish: 82%
Target Information
TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein, although a smaller biologically active form can also be generated by cleavage near the cell membrane.
TWEAK has multiple biological activities, including:
- Stimulation of cell growth and angiogenesis
- Induction of inflammatory cytokines
- Stimulation of apoptosis
The TWEAK signal transduction pathway appears to signal via TweakR/Fn14, similar to other TNFSF members that bind receptors lacking death domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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