Thermo Fisher Scientific IGF2R Monoclonal Antibody (MEM-238), FITC
IGF2R 단백질을 인식하는 Mouse IgG1 형 단클론 항체로, FITC 형광으로 표지되어 있습니다. Flow Cytometry에 적합하며 인간 시료에서 검증되었습니다. 4°C 암소 보관, 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-238 |
| Immunogen | Recombinant Vaccinia virus encoding CD222 |
| Conjugate | FITC (Fluorescein) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Storage conditions | 4°C, store in dark |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2534524 |
Additional Formats
- Unconjugated
- Alexa Fluor 647
- APC
- Biotin
- PE
- Request custom conjugation
Target Information
Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are transported within the cell by approximately 300 kDa cation-independent mannose 6-phosphate receptors (CI-MPR). These receptors participate in both biosynthetic and endocytic cycles, moving lysosomal enzymes between the trans-Golgi network, endosomes, and the plasma membrane. MPRs cycle through these compartments roughly every 3 hours, with most located in late endosomes, fewer in the trans-Golgi network, and about 10% at the cell surface.
The MPR also binds type II insulin-like growth factor (IGF-II), allowing simultaneous binding of man6P and IGF-II. A soluble ~240 kDa truncated form representing the extracellular domain circulates in serum and retains ligand-binding capability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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