Thermo Fisher Scientific Human ADAM17 Synthetic Peptide
인간 ADAM17 단백질의 카르복시 말단 근처 17개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. 폴리클로날 항체 PA5-19872의 블로킹 펩타이드로 활용 가능하며, 다양한 세포 표면 단백질 절단 연구에 적합합니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PEP0008
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human ADAM17 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human TACE.
PEP-0008 can be used as a blocking peptide with polyclonal antibody PA5-19872.
Target Information
ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.
It is responsible for the proteolytic release of soluble JAM3 and other cell-surface proteins including:
- p75 TNF-receptor
- Interleukin receptor type II
- p55 TNF-receptor
- Transforming growth factor-alpha
- L-selectin
- Growth hormone receptor
- MUC1
- Amyloid precursor protein
ADAM17 also acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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