Thermo Fisher Scientific Human ADAM17 Synthetic Peptide

Thermo Fisher Scientific Human ADAM17 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the carboxy terminus of human TACE.
PEP-0008 can be used as a blocking peptide with polyclonal antibody PA5-19872.

Target Information

ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.
It is responsible for the proteolytic release of soluble JAM3 and other cell-surface proteins including:

• p75 TNF-receptor
• Interleukin receptor type II
• p55 TNF-receptor
• Transforming growth factor-alpha
• L-selectin
• Growth hormone receptor
• MUC1
• Amyloid precursor protein

ADAM17 also acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.