Thermo Fisher Scientific CBX4 Polyclonal Antibody
CBX4 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC에 사용 가능. 인간과 마우스에 반응하며, 동결건조 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 100–150 of mouse CBX4 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse.
- Specificity: CBX4.
Target Information
Polycomb group (PcG) proteins are chromatin-associated proteins important for embryonic and adult stem cell self-renewal and maintenance.
At least two distinct human PcG complexes have been identified.
Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1, and RING domain-containing proteins (RING1, RING2, and BMI1).
CBX4 (Chromobox protein homolog 4 or PC2) functions as a transcriptional suppressor and acts as an E3 SUMO-protein ligase facilitating SUMO1 conjugation.
Depletion of CBX4 results in decreased cellular resistance to ionizing radiation and is directly involved in the cellular response to DNA damage.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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