Thermo Fisher Scientific CBX5 Polyclonal Antibody
Thermo Fisher Scientific의 CBX5 폴리클로날 항체는 마우스 CBX5 단백질을 인식하며 WB 및 IHC에 사용됩니다. 동결건조 형태로 제공되며, 4°C 단기 보관 또는 -20°C 장기 보관이 가능합니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 50–100 of mouse CBX5 conjugated to an immunogenic carrier protein was used as the antigen. Target family: HP1 alpha (UniProt ID: Q61686-1). |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: CBX5.
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. Mammalian methyltransferases that selectively methylate histone H3 on lysine-9 create a binding site for HP1 proteins, which are adaptor molecules involved in gene silencing and chromatin structure.
The HP1 chromodomain specifically recognizes methylated histone H3 at lysine-9. In Suv39h double-mutant mouse fibroblasts, heterochromatin association of HP1 is lost but restored upon reintroduction of catalytically active SUV39H1 HMTase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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