Thermo Fisher Scientific PEN2 Polyclonal Antibody
PEN2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 인간, 마우스, 랫트 반응성을 가지며, 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 13 amino acid peptide from near the amino terminus of human PEN2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155987 |
Product Specific Information
- Suggested positive control: A-20 cell lysate
- PA5-20302 can be used with blocking peptide PEP-0427.
Target Information
Presenilins are components of the gamma-secretase protein complex, required for intramembranous processing of type I transmembrane proteins such as Notch and beta-amyloid precursor protein. Notch receptor signaling mediates diverse developmental cell fates, while processing of beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques in Alzheimer’s disease. The PEN2 protein is essential for Notch pathway signaling and gamma-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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