Thermo Fisher Scientific DC-SIGN Polyclonal Antibody
DC-SIGN 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 양 시료에 반응합니다. Western blot, IHC(F), ICC/IF 등 다양한 응용에 사용 가능하며, 합성 펩타이드(aa 277-293)를 면역원으로 제작되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Sheep |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 277–293 of human DC-SIGN |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2291259 |
Product Specific Information
PA1-30119 detects DC-SIGN from human samples.
Target Information
This gene encodes a transmembrane receptor often referred to as DC-SIGN due to its expression on dendritic cells and macrophages. The encoded protein participates in the innate immune system and recognizes a wide range of pathogens including parasites and viruses.
It consists of three main domains:
- N-terminal transmembrane domain
- Tandem-repeat neck domain
- C-type lectin carbohydrate recognition domain
The extracellular region (neck + lectin domains) functions both as a pathogen recognition receptor and a cell adhesion receptor. The neck region facilitates homo-oligomerization, enabling multivalent ligand binding with high avidity.
Variations in the number of 23 amino acid repeats in the neck domain affect ligand binding ability.
DC-SIGN is closely related to L-SIGN (GeneID 10332) but differs in ligand-binding properties and tissue distribution.
Alternative splicing produces multiple variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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