Thermo Fisher Scientific SCNN1G Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Glycerol (1:1) may be added for additional stability.
• Reconstitute in 100 µL of sterile water.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels.
Members of this family share structural similarities, including two short intracellular amino and carboxyl termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.

There are three homologous isoforms of ENaC: alpha, beta, and gamma.
ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. It also mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure.

ENaC function is partly regulated through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.
Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.