Thermo Fisher Scientific SCNN1D Polyclonal Antibody
SCNN1D 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, IHC에 적합합니다. 합성 펩타이드를 면역원으로 사용했으며, 비결합형 동결건조 형태로 제공됩니다. 단기 보관은 4°C, 장기 보관은 -20°C에서 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the extracellular domain of human amiloride-sensitive sodium channel subunit delta (SCNN1D, SCNED, Delta-ENaC) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: SCNN1D.
Target Information
SNX6 interacts with members of the transforming growth factor-beta (TGF-β) receptor family of serine-threonine kinases. These receptors include type II receptors that bind ligand and type I receptors that are subsequently recruited to transduce the signal.
SNX6 strongly interacts with ActRIIB and more moderately with wild-type and kinase-defective mutants of TβRII. Among type I receptors, SNX6 interacts only with inactivated TβRI.
SNXs 1–4 also interact with the TGF-β receptor family, showing different receptor preferences. Conversely, SNX6 behaves similarly to other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions among SNX1, -2, -4, and -6 suggest the formation of oligomeric complexes in vivo.
These findings provide the first evidence of association between the SNX family and receptor serine-threonine kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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