Thermo Fisher Scientific PAK2 Polyclonal Antibody
PAK2 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. IHC, ICC, ELISA 등 다양한 응용에 사용 가능하며, Protein A 정제 및 고농도(1 mg/mL) 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human PAK2 (amino acids 41–140) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PAK2 (Serine/threonine-protein kinase PAK2) is a serine/threonine kinase involved in various signaling pathways, including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis, and proliferation. It functions as a downstream effector of the small GTPases CDC42 and RAC1. Activation occurs through binding with active CDC42 and RAC1, leading to conformational changes and autophosphorylation on multiple serine/threonine residues. Full-length PAK2 promotes cell survival and growth. PAK proteins link Rho GTPases to cytoskeleton reorganization and nuclear signaling and are key regulators of diverse biological processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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