Thermo Fisher Scientific FADD Recombinant Rabbit Monoclonal Antibody (23GB3590)
FADD 단백질을 인식하는 토끼 모노클로날 항체로, Western blot, ICC/IF, Flow Cytometry에 사용 가능. HEK293F 발현 시스템에서 제조된 recombinant 항체로 높은 특이성과 재현성을 제공. PBS/glycerol buffer에 보관되며 -20°C에서 안정적으로 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB3590 |
| Immunogen | A synthetic peptide of human FADD (150–205AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.85 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The FADD protein acts as an adaptor molecule that interacts with various cell surface receptors and mediates apoptotic signals. Through its C-terminal death domain, it can be recruited by receptors such as Fas, TNFRSF25, and TRAIL-receptor, participating in death signaling. This interaction exposes the N-terminal effector domain, allowing recruitment of caspase-8 and activation of the cysteine protease cascade. Knockout studies in mice highlight its role in early T cell development.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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