Thermo Fisher Scientific TNFAIP3 Polyclonal Antibody, FITC
TNFAIP3 단백질을 표적으로 하는 FITC 결합 Rabbit Polyclonal Antibody. Western blot, ELISA, Immunoprecipitation 등 다양한 응용 가능. Human, Mouse, Rat 등 다종 반응성. 고순도 친화크로마토그래피 정제, 암 연구 및 염증 반응 조절 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 690–790 of human TNFAIP3 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region often deleted in B cell lymphomas. It functions as a tumor suppressor gene in Hodgkin lymphoma and several non-Hodgkin lymphoma subtypes. TNFAIP3 encodes a zinc-finger protein rapidly induced by TNF-α, inhibiting NF-κB-dependent gene expression and protecting cells from TNF-α cytotoxicity. Overexpression of TNFAIP3 inhibits TLR2- and TLR4-mediated IL-8 synthesis in airway epithelial cells, acting as a negative regulator of TLR-mediated inflammatory responses. At least two isoforms of TNFAIP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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