Thermo Fisher Scientific CD3e Chimeric Recombinant Rabbit Monoclonal Antibody (145-2C11)
Thermo Fisher Scientific의 CD3e Chimeric Rabbit Monoclonal Antibody (145-2C11)은 마우스 CD3e 단백질을 인식하는 재조합 항체로, WB, Flow Cytometry, IP, T-Cell Activation에 사용됩니다. HEK293 세포에서 발현되며 Protein A로 정제된 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| T-Cell Activation (TCA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 145-2C11 |
| Immunogen | H-2Kb-specific murine cytotoxic T-lymphocyte (CTL) clone |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074211 |
Product Specific Information
Specificity: Recognises a 25-kDa protein component (CD3e, originally called T3-e) of the antigen-specific T-cell receptor.
Target Information
The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and regulating the surface expression of the TCR complex.
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of CD3 gamma, delta, epsilon, and zeta subunits. These subunits are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.
CD3 components have long cytoplasmic tails that associate with signal transduction molecules, mediated by a double tyrosine-based motif.
CD3 is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells.
Defects in the CD3 gene are associated with CD3 immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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