Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI1A6), TrueMAB
TYMS 단백질을 인식하는 Mouse monoclonal antibody로, Western blot과 IHC(P)에서 검증됨. Human 시료에 반응하며, Affinity chromatography로 정제된 액상 항체. DNA 합성 관련 효소 Thymidylate Synthase 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A6 |
| Immunogen | Full-length human recombinant TYMS protein produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Thymidylate Synthase (TS) catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), a key step in DNA biosynthesis. TS is a critical target for fluoropyrimidine-based chemotherapeutic agents such as 5-fluorouracil (5-FU) and fluorodeoxyuridine, which inactivate TS through the formation of a ternary covalent complex with the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein correlates with response to 5-FU in several human cancers, including colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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