
Thermo Fisher Scientific CRYAB Monoclonal Antibody (1A10-1A4)
CRYAB 단백질을 표적으로 하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody(클론 1A10-1A4). Western blot과 ELISA에 적합하며, 인간 단백질에 반응. 고순도 Affinity chromatography 정제, 액상 형태로 제공. 연구용 전용.
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Thermo Fisher Scientific CRYAB Monoclonal Antibody (1A10-1A4)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A10-1A4 |
| Immunogen | CRYAB (AAH07008, 1–175 a.a.) full-length recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW FDTGLPEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK RVSGPERTIP ITREEKPAVT AAPKK
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to maintain the proper refractive index. The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.
Alpha-crystallin is the largest and composed of two primary gene products, alpha-A and alpha-B. Alpha-B crystallin (CRYAB) functions as a molecular chaperone, preventing protein aggregation and potentially reducing cataract formation. It is also implicated in Alexander’s disease, where accumulation occurs in brain cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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