Thermo Fisher Scientific CRYAB Monoclonal Antibody (S4)

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW FDTGLPEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK RVSGPERTIP ITREEKPAVT AAPKK

Target Information

Lens proteins consist almost entirely of crystallins (about 95%), which are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to maintain the proper refractive index.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.

• Alpha-crystallin is the largest, composed of alpha-A and alpha-B gene products, and makes up about 40% of total lens protein.
• It functions as a molecular chaperone, preventing aggregation that could lead to cataract formation.
• Phosphorylation of alpha-crystallin occurs in response to cellular stress and may regulate structural stability and protein maintenance.
• Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.