Thermo Fisher Scientific CERKL Polyclonal Antibody
CERKL 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. 인간 및 생쥐 시료에 반응하며 WB, IHC, ICC/IF에 적합. 고순도 친화 크로마토그래피 정제, 액상 형태, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CERKL (Accession Q49MI3), corresponding to amino acid residues L341–S391 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853831 |
Product Specific Information
Antibody detects endogenous levels of total CERKL.
Target Information
This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. It encodes a protein with ceramide kinase-like domains; however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may act as a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing results in multiple transcript variants encoding different isoforms and non-coding transcripts.
[provided by RefSeq, May 2010]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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