Thermo Fisher Scientific UNG Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Immunogen sequence: MIGQKTLYSF FSPSPARKRH APSPEPAVQG TGVAGVPEES GDAAAIPAKK APAGQEEPGT PPSSPLSAEQ LDRIQRNKAA ALLRLAARNV PVGFGESWKK
• Positive Samples: Mouse skeletal muscle, Mouse heart, Rat skeletal muscle
• Cellular Location: Mitochondrion, Nucleus

Target Information

The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase. These forms are generated by alternative splicing and the use of two differentially regulated promoters, PA and PB.
UNG1 and UNG2 cDNAs are similar in size (2061 and 2058 bp, respectively), and the corresponding mRNAs are not resolved as distinct species in gel electrophoresis.
Nuclear UNG2 differs from mitochondrial UNG1 in 44 amino acids of the N-terminal sequence, which is not necessary for catalytic activity.
UNG gene products repair mutagenic U:G mispairs caused by cytosine deamination; for example, UNG2 removes misincorporated dUMP residues.
Expression of UNG1 and UNG2 varies by cell and tissue type and is cell cycle regulated. UNG expression and activity are generally higher in proliferating cells.
UNG1 is a 304 amino acid protein, and UNG2 is a 313 amino acid protein.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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