Thermo Fisher Scientific UNG Polyclonal Antibody
Thermo Fisher Scientific의 UNG Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 Rabbit IgG 폴리클로날 항체입니다. Western blot, ICC/IF, ELISA에 적합하며, 액상 형태로 제공됩니다. PBS buffer와 50% glycerol 포함, -20°C에서 보관이 권장됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human UNG (NP_5504331) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.17 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805309 |
Product Specific Information
- Immunogen sequence: MIGQKTLYSF FSPSPARKRH APSPEPAVQG TGVAGVPEES GDAAAIPAKK APAGQEEPGT PPSSPLSAEQ LDRIQRNKAA ALLRLAARNV PVGFGESWKK
- Positive Samples: Mouse skeletal muscle, Mouse heart, Rat skeletal muscle
- Cellular Location: Mitochondrion, Nucleus
Target Information
The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase. These forms are generated by alternative splicing and the use of two differentially regulated promoters, PA and PB.
UNG1 and UNG2 cDNAs are similar in size (2061 and 2058 bp, respectively), and the corresponding mRNAs are not resolved as distinct species in gel electrophoresis.
Nuclear UNG2 differs from mitochondrial UNG1 in 44 amino acids of the N-terminal sequence, which is not necessary for catalytic activity.
UNG gene products repair mutagenic U:G mispairs caused by cytosine deamination; for example, UNG2 removes misincorporated dUMP residues.
Expression of UNG1 and UNG2 varies by cell and tissue type and is cell cycle regulated. UNG expression and activity are generally higher in proliferating cells.
UNG1 is a 304 amino acid protein, and UNG2 is a 313 amino acid protein.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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