Thermo Fisher Scientific APE1 Monoclonal Antibody (2104)
APE1 단백질을 인식하는 Thermo Fisher Scientific의 mouse monoclonal 항체. Western blot, IHC, ICC, ELISA 등에 사용 가능. Human 및 Mouse 반응성. 고순도 Protein G 정제, 보존제 무첨가 PBS 용액 형태. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:5,000 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| ELISA | 1:1,000–1:10,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2104 |
| Immunogen | Full length human APE1 purified from E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.2 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787213 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: HepG2, HeLa, Raji whole cell lysates.
- Centrifuge briefly prior to opening the vial.
Target Information
Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional enzyme involved in DNA repair and redox regulation of various transcription factors such as Fos, Jun, NF-kB, Myb, HIF-1α, CREB, Pax, and p53.
APE repairs abasic sites in DNA caused by spontaneous loss or oxidative damage, chemotherapy, ionizing radiation, UV irradiation, and removal of modified bases by DNA glycosylases.
Expression levels vary across tissues and developmental stages, and its localization suggests interactions with multiple cellular proteins beyond nuclear DNA repair.
Phosphorylation-mediated regulation by casein kinase II has been reported. Increased APE levels are observed upon reoxygenation of hypoxic cells and in some malignant tissues, while decreased expression is associated with apoptosis induction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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