Thermo Fisher Scientific Perforin Polyclonal Antibody
Perforin 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB 및 IHC(P) 실험에 적합. 사람, 마우스, 랫트 반응성. Rabbit IgG로 제작, 액상 형태, 1 mg/mL 농도. 면역세포 관련 연구 및 세포독성 단백질 분석에 활용 가능.
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Thermo Fisher Scientific Perforin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRF1 (Accession P14222), corresponding to amino acid residues T74–S124 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851712 |
Product Specific Information
Antibody detects endogenous levels of total PRF1.
Target Information
Perforin is one of the major cytolytic proteins of cytolytic granules. It acts as a cytolytic mediator stored and released by cytoplasmic granules and is involved in immune defense against tumors and viral infections mediated by cytotoxic lymphocytes.
Perforin is a 555 amino acid protein with a 21 amino acid signal peptide and has a molecular weight of 70–75 kDa. It forms transmembrane channels similar to complement component C9, showing structural homology.
Expression of perforin is restricted to killer cell lines and absent in helper T lymphocytes or other tumor cells. It is a key effector molecule for T-cell and natural killer cell-mediated cytolysis.
Defects in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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