Thermo Fisher Scientific PDGF-C Polyclonal Antibody
PDGF-C 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot과 ELISA에 사용 가능. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며, -20°C에서 보관.
- 카탈로그번호
- PA112720
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:50–1:200 | - |
| ELISA | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the N-terminal region of Sphingosine Kinase 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2195985 |
Product Specific Information
A suggested positive control for this product is active recombinant sphingosine kinase enzyme.
Target Information
Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), a key signaling molecule with intra- and extracellular roles. Inside the cell, S1P functions similarly to other sphingolipid metabolites such as ceramide and sphingosine. It is involved in regulating cell differentiation, calcium mobilization, and apoptosis.
S1P receptors belong to the EDG family of G protein-coupled receptors (S1P Receptors). These receptors interact with multiple G proteins (e.g., S1P1 with Gi, S1P2 and S1P3 with Gq, G13, and Gi), influencing processes such as cell motility, survival, apoptosis, migration, and cell–cell interactions. S1P also plays crucial roles in cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, and neural and bone cell regulation. S1P levels are controlled by the activity of Sphk enzymes (Sphk1 and Sphk2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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