Thermo Fisher Scientific KLRG1 Monoclonal Antibody (13F12F2), APC, eBioscience

Thermo Fisher Scientific KLRG1 Monoclonal Antibody (13F12F2), APC, eBioscience™

Applications

• Flow Cytometry (Flow): 5 µL (0.25 µg)/test
• View 6 publications

Product Specifications

Additional Formats

• Alexa Fluor 488
• Alexa Fluor 647
• APC-eFluor 780
• Brilliant UV 395
• Brilliant UV 737
• Brilliant Violet 480
• Brilliant Violet 786
• Functional Grade
• PE
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Super Bright 600
• Super Bright 702
• Request custom conjugation

Product Specific Information

This 13F12F2 monoclonal antibody reacts with human killer cell lectin-like receptor subfamily G, member 1 (KLRG1), a type II transmembrane inhibitory receptor belonging to the C-type lectin superfamily containing an ITIM domain.
KLRG1 is expressed on subsets of γδ T cells, NK (CD56^dim^), CD8+ and CD4+ T cells, primarily by effector/memory phenotype cells that are short-lived but capable of immediate effector function.
Cadherin-E, -N, and -R serve as ligands for KLRG1, and their interaction inhibits cytolytic activity and proliferation. The percentage of KLRG1-positive cells varies depending on antigen exposure.

• Clones 13F12F2 and 13A2 recognize similar epitopes based on cross-blocking studies.
• Applications Reported: Flow cytometric analysis.
• Applications Tested: Pre-titrated and tested by flow cytometric analysis of human peripheral blood cells at 5 µL (0.25 µg)/test.
• Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
• Filtration: 0.2 µm post-manufacturing filtered.

Target Information

KLRG1 (Killer cell lectin-like receptor G1, MAFA, 2F1-Ag) is a homodimeric member of the lectin-like type II transmembrane receptor family that contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domains.
These ITIMs interact with SH2 domains of phosphatases such as SHP-1.
KLRG1 acts as an inhibitory receptor expressed on NK cells and certain T cells, which are involved in tumor and virus-infected cell lysis and mediate humoral and cell-mediated immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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