Thermo Fisher Scientific KLRG1 Monoclonal Antibody (13F12F2), APC, eBioscience
인간 KLRG1 단백질을 인식하는 13F12F2 클론의 APC 결합 단일클론 항체로, NK 및 T 세포의 흐름세포분석(Flow Cytometry)에 최적화되어 있습니다. 633–647 nm 적색 레이저에 적합하며, 4°C 암소 보관이 필요합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific KLRG1 Monoclonal Antibody (13F12F2), APC, eBioscience™
Applications
- Flow Cytometry (Flow): 5 µL (0.25 µg)/test
- View 6 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 13F12F2 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573302 |
Additional Formats
- Alexa Fluor 488
- Alexa Fluor 647
- APC-eFluor 780
- Brilliant UV 395
- Brilliant UV 737
- Brilliant Violet 480
- Brilliant Violet 786
- Functional Grade
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 600
- Super Bright 702
- Request custom conjugation
Product Specific Information
This 13F12F2 monoclonal antibody reacts with human killer cell lectin-like receptor subfamily G, member 1 (KLRG1), a type II transmembrane inhibitory receptor belonging to the C-type lectin superfamily containing an ITIM domain.
KLRG1 is expressed on subsets of γδ T cells, NK (CD56^dim^), CD8+ and CD4+ T cells, primarily by effector/memory phenotype cells that are short-lived but capable of immediate effector function.
Cadherin-E, -N, and -R serve as ligands for KLRG1, and their interaction inhibits cytolytic activity and proliferation. The percentage of KLRG1-positive cells varies depending on antigen exposure.
- Clones 13F12F2 and 13A2 recognize similar epitopes based on cross-blocking studies.
- Applications Reported: Flow cytometric analysis.
- Applications Tested: Pre-titrated and tested by flow cytometric analysis of human peripheral blood cells at 5 µL (0.25 µg)/test.
- Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
- Filtration: 0.2 µm post-manufacturing filtered.
Target Information
KLRG1 (Killer cell lectin-like receptor G1, MAFA, 2F1-Ag) is a homodimeric member of the lectin-like type II transmembrane receptor family that contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domains.
These ITIMs interact with SH2 domains of phosphatases such as SHP-1.
KLRG1 acts as an inhibitory receptor expressed on NK cells and certain T cells, which are involved in tumor and virus-infected cell lysis and mediate humoral and cell-mediated immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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