Thermo Fisher Scientific IDO1 Monoclonal Antibody (UMAB251), UltraMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

IDO1 (Indoleamine 2,3-dioxygenase 1) is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of key regulatory molecules such as tryptophan, serotonin, and melatonin.
This reaction initiates the formation of biologically active metabolites known as kynurenines. IDO1 is expressed in various human tissues, macrophages, and dendritic cells. During inflammation, interferons induce IDO1 expression, contributing to antimicrobial mechanisms by depleting tryptophan and inhibiting pathogen growth.
IDO1 also plays a crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.