Thermo Fisher Scientific KV1.1 (KCNA1) Polyclonal Antibody

Thermo Fisher Scientific KV1.1 (KCNA1) Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution

• 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: ISIVIFCLET LPELKDDKDF TGTVHRIDNT TVIYNSNIFT DPFFIVETLC
• Sequence homology:
  Dog: 100%
  Guinea Pig: 79%
  Horse: 86%
  Human: 100%
  Mouse: 93%
  Pig: 100%
  Rat: 93%

Target Information

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments, and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif. The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.