Thermo Fisher Scientific Denintuzumab Humanized Recombinant Human Monoclonal Antibody
CD19을 표적으로 하는 인간화 재조합 단일클론 항체로, ELISA 등 연구용에 적합합니다. CHO 세포에서 발현되며 IgG1, kappa 아이소타입입니다. 단백질 A로 정제된 액상형 제품으로, 내독소 수준이 낮고 장기 보관이 가능합니다.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Human / IgG1, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Immunogen | Human CD19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.38 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911169 |
Product Specific Information
- Endotoxin level: < 0.01 EU/µg by LAL method
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Store at 2–8°C for one week, or at -20 to -80°C for twelve months from the date of receipt.
Target Information
Denintuzumab is a biosimilar antibody that targets CD19.
CD19 is a member of the immunoglobulin superfamily with two Ig-like domains and is expressed on 100% of peripheral B cells. It may also be expressed on myeloid leukemia cells, particularly those of monocytic lineage.
CD19 serves as a key functional regulator of B cell proliferation and differentiation, acting as a signal-amplifying coreceptor for the B cell receptor (BCR). Mutations in CD19 can cause hypogammaglobulinemia, while overexpression leads to B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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