Thermo Fisher Scientific Plasma Kallikrein Polyclonal Antibody
Human plasma kallikrein 인식 토끼 폴리클로날 항체로, Western blot에 최적화되어 있습니다. 중간 영역 펩타이드를 면역원으로 사용하며, Protein A로 정제된 액상 형태입니다. PBS와 sucrose 완충액에 보관하며, 연구용으로만 사용 가능합니다.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human KLKB1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609768 |
Product Specific Information
- Peptide sequence: VLTAAHCFDG LPLQDVWRIY SGILNLSDIT KDTPFSQIKE IIIHQNYKVS
- Sequence homology: Dog: 86%; Horse: 86%; Human: 100%; Pig: 79%; Rat: 79%
Target Information
Plasma prekallikrein is a glycoprotein involved in surface-dependent activation of blood coagulation, fibrinolysis, kinin generation, and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Upon activation by factor XIIa, plasma prekallikrein is converted to plasma kallikrein by cleavage of an internal Arg-Ile bond.
Plasma kallikrein consists of a heavy chain and a light chain linked by a disulfide bond. The heavy chain contains four tandem repeats of approximately 90 amino acids, each forming an apple domain, which contributes to its pro-coagulant activity. The light chain carries the catalytic domain homologous to the trypsin family of serine proteases. Deficiency of plasma prekallikrein can cause prolonged activated partial thromboplastin time in patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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