Thermo Fisher Scientific TFF2 Polyclonal Antibody
Human TFF2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(Paraffin)에서 1:2,500~1:5,000 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 및 글리세롤 버퍼에 보관. 위장관 상피 보호 및 재생 관련 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:2,500–1:5,000
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TFF2. Recombinant protein control fragment (Product #RP-95295). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648410 |
Product Specific Information
- Immunogen sequence:
PHNRTNCGFP GITSDQCFDN GCCFDSSVTG VPWCFHPLPK QESDQCVMEV SDRRNCGYPG ISPEECASRK CCFSNFIFEV PWC - Highest antigen sequence identity to orthologs:
- Mouse: 87%
- Rat: 83%
Target Information
Trefoil peptides are protease-resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia.
These peptides contain three intrachain disulfide bonds forming the trefoil motif (P-domain).
SP (spasmolytic polypeptide), also known as Trefoil factor 2 (TFF2) precursor, inhibits gastrointestinal motility and gastric acid secretion.
SP may act as a structural component of gastric mucus, stabilizing glycoproteins through carbohydrate side chain interactions.
Downregulation of SP expression is associated with primary gastric cancer, and its progressive loss may be involved in early gastric carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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