Thermo Fisher Scientific Phospho-ABCB11 (Ser690) Polyclonal Antibody
ABCB11 단백질의 Ser690 인산화 부위를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 IHC(P)에서 검증됨. 사람과 생쥐 시료에 반응. 액상 형태로 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ABCB11 (Accession O95342), corresponding to amino acid residues around phosphorylated Ser690 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816796 |
Product Specific Information
This antibody detects endogenous levels of ABCB11 only when phosphorylated at Ser690.
Target Information
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominantly in the liver, where it is localized to the canalicular microvilli and subcanalicular vesicles of hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP-binding cassette (ABC) domain.
Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2), an inherited liver disease of childhood characterized by cholestasis and normal serum gamma-glutamyltransferase activity.
Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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