Thermo Fisher Scientific EAPP Polyclonal Antibody
Thermo Fisher Scientific의 EAPP Polyclonal Antibody는 rat EAPP 단백질의 N말단 펩타이드를 인식하는 rabbit polyclonal 항체입니다. Western blot에 적합하며, 세포 주기 조절 및 세포자멸사 관련 연구에 활용됩니다. 액상 형태로 -20°C에서 보관합니다.
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Applications
- Western Blot (WB): 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of rat EAPP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2691385 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Target Information
This protein may play an important role in the fine-tuning of both major E2F1 activities — the regulation of the cell cycle and the induction of apoptosis. It promotes S-phase entry and inhibits p14(ARP) expression. The E2F family is crucial in controlling the cell cycle and tumor suppressor protein actions, and is targeted by transforming proteins of small DNA tumor viruses.
E2F proteins contain conserved domains including:
- DNA binding domain
- Dimerization domain (interaction with DP proteins)
- Transactivation domain (acidic amino acids)
- Tumor suppressor protein association domain (within transactivation domain)
The C-terminal of EAPP binds the N-terminal of E2F1 and interacts with E2F2 and E2F3, but not E2F4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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