Thermo Fisher Scientific TDP1 Polyclonal Antibody
Thermo Fisher Scientific의 TDP1 Polyclonal Antibody는 마우스 TDP1 단백질을 인식하는 Rabbit IgG 기반 항체입니다. Western blot에 1.0 µg/mL로 최적화되어 있으며, 액상 형태로 제공됩니다. DNA 손상 복구 관련 연구에 적합하며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region of mouse TDP1 (amino acids 350–399, UniProt ID: Q8BJ37-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2691045 |
Product Specific Information
This target displays homology in the following species:
- Cow: 92%
- Dog: 93%
- Guinea Pig: 100%
- Horse: 100%
- Human: 100%
- Mouse: 86%
- Rabbit: 93%
- Rat: 100%
Target Information
The TDP1 protein is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3′ phosphate of DNA. It may also remove glycolate from single-stranded DNA containing 3′ phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks.
This gene belongs to the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations are associated with spinocerebellar ataxia with axonal neuropathy (SCAN1). Two major transcript variants encode the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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