Thermo Fisher Scientific GPR49/LGR5 Polyclonal Antibody
GPR49/LGR5 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat에 반응하며 Protein A로 정제된 고품질 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from mouse GPR49, amino acids 810–907 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
G protein-coupled receptor GPR49 (also known as LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries, as well as from germ cell, uterus, and brain libraries.
G-protein Coupled Receptors (GPCRs) form one of the largest families of signaling molecules, with over a thousand predicted members. They share a common structure of seven membrane-spanning helices and exist in both active and inactive forms.
Activation of GPCRs triggers signaling via G-proteins and downstream effectors, while regulatory mechanisms control their deactivation. This dynamic signaling plays a crucial role in cellular physiology and pharmacological research. Notably, GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) are major therapeutics in mental health and allergy treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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