Thermo Fisher Scientific CDNF Polyclonal Antibody
CDNF 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF에 적합. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며 1 mg/mL 농도의 액상 형태. 파킨슨병 연구 등 신경세포 보호 기전 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 9 amino acid peptide from near the carboxy terminus of human CDNF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153034 |
Product Specific Information
- Suggested positive control: Mouse brain tissue lysate
- PA5-20429 can be used with blocking peptide PEP-0546.
Target Information
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and is highly homologous to mesencephalic astrocyte-derived neurotrophic factor (MANF).
CDNF is expressed at higher levels in tissues such as heart, skeletal muscle, and testes than in brain. Similar to glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent 6-hydroxydopamine (6-OHDA) induced degeneration of dopaminergic neurons in rat models of Parkinson’s disease.
Furthermore, CDNF can restore dopaminergic function and prevent degeneration of dopaminergic neurons in the substantia nigra, suggesting potential therapeutic applications for Parkinson’s disease.
At least two isoforms of CDNF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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