Thermo Fisher Scientific CDNF Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

2-4 µg/mL

-

Immunohistochemistry (IHC)

2.5 µg/mL

-

Immunocytochemistry (ICC/IF)

20 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

a 9 amino acid peptide from near the carboxy terminus of human CDNF. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CDNF,uniProtId:Q49AH0-1,ncbiNodeId:9606,antigenRange:187,antigenLength:187,antigenImageFileName:PA5-20429_CDNF_Q49AH0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-20429_CDNF_Q49AH0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11153034

Product Specific Information

A suggested positive control is mouse brain tissue lysate.

PA5-20429 can be used with blocking peptide PEP-0546.

Target Information

The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6 OHDA) induced degeneration of dopaminergic neurons in a rat model of Parkinsons disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinsons disease. At least two isoforms of CDNF are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.