Thermo Fisher Scientific ICAD Polyclonal Antibody
ICAD 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC/IF에 사용 가능. 고순도(>95%) 항체로 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, 장기 보관 시 -20°C 권장.
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- PA586422
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 151–200 of Human ICAD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803200 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
ICAD (Inhibitor of Caspase-Activated DNase) is a substrate that regulates nuclear apoptosis by inhibiting CAD (Caspase-Activated DNase).
ICAD has two isoforms:
- ICAD-L/DFF45 (45 kDa): Functional isoform
- ICAD-S/DFF35 (35 kDa): Non-functional isoform
ICAD-L binds and inhibits CAD, but is cleaved by caspase-3 at residues 117 and 224 during apoptosis, releasing CAD to execute DNA fragmentation.
In non-apoptotic cells, CAD remains complexed with ICAD.
ICAD also functions as a CAD-specific folding chaperone.
Recent studies suggest ICAD may be a potential therapeutic target for restoring normal apoptotic signaling in colon and brain cancer cells.
Two alternatively spliced transcript variants encoding distinct isoforms have been identified for the ICAD gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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