Thermo Fisher Scientific NUSAP1 Polyclonal Antibody
Thermo Fisher Scientific의 NUSAP1 Polyclonal Antibody는 인간 NUSAP1 단백질을 인식하는 토끼 유래 다클론 항체입니다. ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 완충액에 보관되며, 연구용으로만 사용됩니다.
- 카탈로그번호
- PA5111726
- 판매단위
- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NUSAP1. Recombinant protein control fragment: Product #RP-108641 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857136 |
Product Specific Information
Immunogen sequence:
THKLKTITGN SAAVITPFKL TTEATQTPVS NKKPVFDLKA SLSRPLNYEP HKGKLKPWGQ SKENNYLNQH VNRINFYKKT YKQPHLQ
Target Information
Ubiquitin:
Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains), or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).
Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue linked:
- Lys-6-linked: DNA repair
- Lys-11-linked: ERAD and cell-cycle regulation
- Lys-29-linked: Lysosomal degradation
- Lys-33-linked: Kinase modification
- Lys-48-linked: Protein degradation via proteasome
- Lys-63-linked: Endocytosis, DNA-damage response, NF-kappa-B activation
Linear polymer chains via initiator Met lead to cell signaling.
Free (unanchored) polyubiquitin also has distinct roles such as activation of protein kinases and signaling.
60S ribosomal protein L40:
Component of the 60S subunit of the ribosome. Essential for translation of a subset of cellular transcripts, particularly for cap-dependent translation of vesicular stomatitis virus mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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