Thermo Fisher Scientific PRDM16 Polyclonal Antibody
PRDM16 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체로, 인간 및 생쥐 시료에 반응합니다. Flow Cytometry와 ChIP assay에 사용 가능하며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 10 µg/mL
ChIP Assay (ChIP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-TSESGAFHPINHL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932678 |
Product Specific Information
- This antibody is expected to recognize both reported isoforms.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
PRDM16 is a zinc finger transcription factor containing an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and is specifically expressed in t(1:3)(p36, q21)-positive MDS/AML. The translocation results in overexpression of a truncated version lacking the PR domain, which may contribute to MDS and AML pathogenesis.
PRDM16 acts as a Smad3 binding protein involved in orofacial development via TGF-beta signaling modulation and controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-142015_PRDM16_Q9HAZ2-1_Goat.svg)
(이미지: PA5-142015_PRDM16_Q9HAZ2-1_Goat_PDP.jpeg)
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