Thermo Fisher Scientific Presenilin-2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitution:
Add 25 µL, 50 µL, or 0.2 mL of double-distilled water (DDW) depending on sample size. The antibody is shipped lyophilized at room temperature. Upon arrival, store at -20°C.
The reconstituted solution can be stored at 4°C, protected from light, for up to one week. For longer-term storage, aliquot and keep at -20°C. Avoid multiple freeze/thaw cycles.
Centrifuge all antibody preparations before use (10,000 × g for 5 min).

Target Information

Mutations in presenilin proteins (PSEN1 or PSEN2) or amyloid precursor protein (APP) are associated with inherited forms of Alzheimer’s disease (AD). These mutations increase production of the longer amyloid-beta form, the main component of amyloid deposits in AD brains.
Presenilins are believed to regulate APP processing via gamma-secretase, which cleaves APP. They may also participate in Notch receptor cleavage, potentially acting as or regulating protease enzymes.
Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.