Thermo Fisher Scientific CHST1 Monoclonal Antibody (543128)
인간 CHST1 단백질을 인식하는 Mouse IgG1 단일클론 항체. IP 및 중화 실험에 사용 가능하며, 단백질 A/G로 정제된 동결건조 형태. 인간에 특이적 반응을 보이며, 재구성 후 0.5 mg/mL 농도로 사용. 연구용으로만 사용 가능.
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Applications
Immunoprecipitation (IP)
- Tested Dilution: Assay-Dependent
Neutralization (Neu)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 543128 |
| Immunogen | CHO-derived recombinant human Carbohydrate Sulfotransferase 1 (CHST1) Arg24–Ser411 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610229 |
Product Specific Information
- In direct ELISAs, approximately 25–100% cross-reactivity with recombinant mouse CHST1 and no cross-reactivity with recombinant human CHST2, 3, 4, 5, 6, 7, 10, and 14 is observed.
- Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
Carbohydrate sulfotransferase 1 (CHST1), also referred to as KSGal6ST or KSST, is a keratan sulfate sulfotransferase. It is predominantly expressed in brain and skeletal muscle and localizes to the trans-Golgi network. CHST1 mediates the sulfation of keratan in the cornea, which is important for maintaining corneal transparency. It catalyzes the transfer of sulfate groups from 3′-phosphoadenosine 5′-phosphosulfate to position six of internal or terminal galactose residues on growing keratan sulfate chains, contributing to L-selectin ligand generation. Mutations in CHST1 may be associated with macular corneal dystrophy (MCD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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