Thermo Fisher Scientific ESCO1 Polyclonal Antibody
Human 및 Mouse에서 반응하는 Rabbit Polyclonal ESCO1 항체로, Western Blot 및 Immunohistochemistry에 적합합니다. 합성 펩타이드 기반 면역원으로 제작되었으며, 고순도 Affinity chromatography 정제. PBS/glycerol buffer에 보관하며 -20°C에서 안정적입니다.
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Thermo Fisher Scientific ESCO1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ESCO1 (Accession Q5FWF5), corresponding to amino acid residues F547–A597 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853274 |
Product Specific Information
Antibody detects endogenous levels of total ESCO1.
Target Information
EFO1 (Establishment factor-like protein 1), also known as ESCO1 (establishment of cohesion 1 homolog1) or ESO1, is a member of the acetyltransferase family (GCN5 subfamily).
It is a ubiquitously expressed nuclear protein that plays an important role in sister chromatid cohesion.
At its C-terminus, EFO1 contains an H2C2 zinc finger motif and an acetyltransferase domain that exhibits acetyltransferase activity in vivo.
Its N-terminus, containing two domains similar to alpha- and beta-type linker histone proteins, is essential for EFO1 association with chromosomes.
EFO1 is responsible for coupling cohesion and DNA replication processes, ensuring proper pairing of sister chromatids.
EFO1 is phosphorylated during mitosis, which may act to regulate EFO1 activity.
Due to alternative splicing events, three EFO1 isoforms exist.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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