Thermo Fisher Scientific Phospho-ATF4 (Ser224) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

Phospho-ATF4 (Ser224) Polyclonal Antibody detects endogenous levels of ATF4 only when phosphorylated at Ser224.

Target Information

This gene encodes a transcription factor originally identified as a widely expressed mammalian DNA-binding protein capable of binding a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also characterized as cAMP-response element binding protein 2 (CREB-2).
It belongs to a family of DNA-binding proteins including AP-1, CREB, and CREB-like proteins. These transcription factors share a leucine zipper region involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids functioning as a DNA-binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.