Thermo Fisher Scientific Phospho-ATM (Ser367) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

Phospho-ATM (Ser367) Polyclonal Antibody detects endogenous levels of ATM only when phosphorylated at Ser367.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by:

• Progressive neurologic degeneration
• Immunologic deficiency
• Increased risk of lymphoid cancer

The ATM gene encodes a protein of the phosphoinositide 3-kinase (PI3K) superfamily.
ATM phosphorylates proteins (not lipids) and regulates cell-cycle proteins such as P53, Mdm2, BRCA1, and SMC1.
ATM is essential for repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens.
The C-terminal region of ATM shares homology with the catalytic domains of PI3 kinases.
ATM becomes autophosphorylated and activated upon exposure to ionizing radiation.
Cells lacking ATM are hypersensitive to radiation, show impaired DNA synthesis inhibition, and delayed p53 induction.
DNA damage activates ATM-kinase, triggering kinase cascades that regulate cell cycle, apoptosis, and DNA repair.
ATM is also linked to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.