Thermo Fisher Scientific P2X2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Immunohistochemistry (IHC)

-

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Immunohistochemistry (Frozen) (IHC (F))

1:1,000

-

Immunocytochemistry (ICC/IF)

1:1,000

View 1 publication 1 publication

Product Specifications

Species Reactivity

Guinea pig, Human, Mouse, Non-human primate, Pig, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues D(460) S T S T D P K G L A Q L(472) of rat P2X2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:P2X2,uniProtId:P49653-1,ncbiNodeId:10114,antigenRange:460-472,antigenLength:472,antigenImageFileName:PA1-24624_P2X2_P49653-1_Rabbit.svg,antigenImageFileNamePDP:PA1-24624_P2X2_P49653-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2157912

Product Specific Information

PA1-24624 is expected to cross react with mouse (100% conserved) and guinea pig (100% conserved) due to sequence homology.

Target Information

P2rx2 are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. P2rx2 functions as a ligand-gated ion channel and binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for P2rx2. P2rx2 is involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, P2rx2 regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. P2rx2 also mediates synaptic transmission between neurons and from neurons to smooth muscle. Diseases associated with P2RX2 include Deafness, Autosomal Dominant 41 and Dfna41 Nonsyndromic Hearing Loss And Deafness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.