Thermo Fisher Scientific Claudin 4 Polyclonal Antibody
Claudin-4 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합합니다. Human에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 냉장 또는 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid synthetic peptide near the carboxy terminus of human CLAUDIN4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551789 |
Product Specific Information
- A suggested positive control is human colon tissue lysate.
- PA5-34437 can be used with blocking peptide PEP-1479.
Target Information
Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins show distinct, tissue-specific expression patterns and are essential components of tight junction charge-specific channels regulating paracellular ion flux.
Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. Overexpression of Claudin-4 decreases paracellular electrical conductance due to selective reduction in Na⁺ permeability, without affecting Cl⁻ permeability.
In ovarian carcinoma cells, Claudin-3 and Claudin-4 are upregulated at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic and other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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