Thermo Fisher Scientific ATP11A Polyclonal Antibody
Rabbit polyclonal antibody targeting human ATP11A 단백질. IHC 및 ICC/IF에 사용 가능하며, 고순도 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관되며, 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ATP11A. Recombinant protein control fragment (Product #RP-94971). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2638346 |
Product Specific Information
Immunogen sequence:
SATGEIYLFC KGADSSIFPR VIEGKVDQIR ARVERNAVEG LRTLCVAYKR LIQEEYEGIC KLLQAAKVAL QDREKKLAEA YEQIEKDLTL LG
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 88%
Target Information
ATP11A is a widely expressed integral membrane ATPase. It is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336, while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Elevated levels of ATP11A mRNA may also serve as a predictive marker of metastasis in colorectal cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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