Thermo Fisher Scientific NDUFAF2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human NDUFAF2 protein. Validated for WB and ICC/IF applications. Detects endogenous NDUFAF2 involved in mitochondrial complex I assembly. Supplied as liquid form, affinity purified, for research use only.
- 카탈로그번호
- PA550452
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635905 |
Product Specific Information
This antibody detects endogenous levels of total NDUFAF2 protein.
Target Information
Mimitin is a small mitochondrial protein whose transcription is directly stimulated by c-Myc and is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in certain cancer cell lines but reduced proliferation in glioblastoma, embryonic lung fibroblastic cells, and ESCC, indicating a specific role in these cells. Mimitin expression is regulated by MAPK kinases and IL-1, but not via the NF-kappa-B pathway. It interacts with microtubular protein MAP1S and influences caspase-3 and -7 activities during apoptosis. Additional studies suggest Mimitin acts as a molecular chaperone for mitochondrial complex I assembly.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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