Thermo Fisher Scientific NOX1 Polyclonal Antibody
NOX1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin, Frozen)에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공. 세포 내 산화 스트레스 및 pH 조절 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human NOX1 (354–374aa, HIRAAGDWTENLIRAFEQQYS). |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide, 0.05 mg thimerosal |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746866 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress.
NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox.
Three splice variants of NOX1 have been identified: NOH-1L, NOH-1S, and NOH-1Lv.
- NOH-1S: Voltage-gated proton channel involved in cellular pH regulation; blocked by zinc.
- NOH-1L: Pyridine nucleotide-dependent oxidoreductase that generates superoxide and may conduct H⁺ ions as part of its electron transport mechanism.
NOX1 has potential therapeutic implications for ischemic diseases.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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