Thermo Fisher Scientific NOD1 Polyclonal Antibody
NOD1 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 및 랫트 시료에 반응합니다. Western blot, IHC, ICC 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 동결건조 형태로 제공되며, 재구성 후 500 µg/mL 농도로 사용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 0.5–1 µg/mL | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human CARD4 recombinant protein (Position: M1–M160) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746862 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, involved in innate immune defense.
It contains:
- An N-terminal caspase recruitment domain (CARD)
- A central nucleotide-binding domain (NBD)
- Ten tandem leucine-rich repeats (LRRs) at the C-terminus
The CARD mediates apoptotic signaling, while NOD1 activates caspase-9 and NF-κB.
LRRs participate in protein–protein interactions, and mutations in the NBD may affect oligomerization and LRR function.
NOD1 acts as an intracellular pattern-recognition receptor (PRR) that triggers inflammation in response to bacteria containing diaminopimelic acid.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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